Asymmetric catalytic transformations of hydrocarbons, including alkanes, alkenes, and aromatics, represent a central frontier in modern synthetic chemistry. These abundant, readily available feedstocks carry inert C–H and C=C bonds. Achieving precise enantiocontrol over their conversion provides a step- and atom-economic strategy to construct enantioenriched chiral molecular scaffolds. Such advances streamline the synthesis of pharmaceuticals, agrochemicals, and functional materials, while laying the foundation for sustainable chemical manufacturing from simple hydrocarbon resources.

n Copper catalyzed asymmetric C(sp³)–H functionalization

n Iridium catalyzed asymmetric C(sp²)–H functionalization

n Electroreduction enabled asymmetric functionalization of arenes