Prof. Qi-Lin Zhou's Research Group

周其林教授课题组主页

Research

Asymmetric hydrogenation

The transition metal-catalyzed asymmetric hydrogenation utilizing molecular hydrogen to reduce prochiral unsaturated bonds is one of the most efficient and atom-economic methods for the preparation of optically active compounds. The chiral spiro ligands including bidentate phosphines SDPs, phosphine-oxazolines SIPHOXs, amino-phosphines SpiroAP, and monodentate phosphorous ligands (SIPHOS and FuPs) exhibited high activity and excellent enantioselectivity in the asymmetric hydrogenations of functionalized olefins (including enamides, enamines, and α,β-unsaturated carboxylic acids), ketones, aldehydes, and imines.

2.1  Hydrogenation of enamides
 

Ref. Chem. Commun. 2002, 480–481.
 Angew. Chem. Int. Ed. 2002, 41, 2348–2350.
 J. Org. Chem. 2004, 69, 4648–4655.
 J. Org. Chem. 2004, 69, 8157–8160.
 

 2.2  Hydrogenation of enamines
 

Ref. J. Am. Chem. Soc. 2006, 128, 11774–11775.
 J. Am. Chem. Soc. 2009, 131, 1366–1367.
 Adv. Synth. Catal. 2009, 351, 3243–3250.
 

 2.3   Hydrogenation of α,β-unsaturated acids

Ref. J. Am. Chem. Soc. 2008, 130, 8584–8585.
 J. Am. Chem. Soc. 2010, 132, 1172–1179.
 
 2.4   Hydrogenation of ketones

Ref. J. Am. Chem. Soc. 2003, 125, 4404–4405.
 J. Am. Chem. Soc. 2010, 132, 4538–4539.

2.5   Hydrogenation of racemic α-substituted aldehydes and ketones via DKR

Ref. J. Org. Chem. 2005, 70, 2967–2973.
 J. Am. Chem. Soc. 2007, 129, 1868–1869.
 Angew. Chem. Int. Ed. 2007, 46, 7506–7508.
 J. Am. Chem. Soc. 2009, 131, 4222–4223.
 Adv. Synth. Catal. 2010, 352, 81–84.
 
 2.6   Hydrogenation of imines
 

Ref. J. Am. Chem. Soc. 2006, 128, 12886–12891.