Prof. Qi-Lin Zhou's Research Group

周其林教授课题组主页

Research

Asymmetric synthesis of biologically active compounds

Various aforementioned catalytic procedures have been applied in the synthesis of biologically active compounds and natural products.
 
 5.1   Synthesis of key intermediate of new blood pressure-lowering drug Aliskiren
 

Ref. J. Am. Chem. Soc. 2008, 130, 8584–8585.

5.2   Synthesis of key intermediate of rupintrivir, a rhinovirus protease inhibitor
 

Ref. J. Am. Chem. Soc. 2010, 132, 1172–1179.

5.3   Synthesis of key intermediate of active form of the anti-inflammatory loxoprofen.
 

Ref. J. Am. Chem. Soc. 2010, 132, 4538–4539.

5.4   Synthesis of leukotriene receptor antagonists BAY X 1005
 

Ref. J. Am. Chem. Soc. 2007, 129, 1868–1869.

5.5   Synthesis of highly selective κ-opioid agonist U-(-)-50488
 

Ref. Angew. Chem. Int. Ed. 2007, 46, 7506–7508.

5.6   Synthesis of isoquinoline alkaloid crispine A

Ref. J. Am. Chem. Soc. 2009, 131, 1366–1367.

5.7    Synthesis of natural product α- and β-conhydrine
 

Ref. Org. Lett. 2009, 11, 4994–4997.