Prof. Qi-Lin Zhou's Research Group

周其林教授课题组主页

Research

Asymmetric carbon-carbon bond-forming reaction

Transition metal-catalyzed asymmetric carbon-carbon bond-forming reaction is essential in modern organic synthesis. Chiral spiro monodentate and bidentate phosphorous ligands have been successfully used in various asymmetric carbon-carbon bond-forming reactions. In most of investigated reactions, the spiro ligands showed superior chiral inducements than the ligands with other backbones.

3.1   Rhodium-catalyzed asymmetric arylation reactions

Ref. Org. Lett. 2006, 8, 1479–1481.
 Org. Lett. 2006, 8, 2567–2569.
 Angew. Chem. Int. Ed. 2008, 47, 4351–4353.

 

  3.2 Nickel-catalyzed three component coupling reaction
 


 Ref. J. Am. Chem. Soc. 2007, 129, 2248–2249.
 J. Am. Chem. Soc. 2008, 130, 14052–14053.
 J. Am. Chem. Soc. 2010, 132, 10955–10957.
 

 3.3    Nickel-catalyzed hydrovinylation reaction
 

Ref. J. Am. Chem. Soc. 2006, 128, 2780–2781.

3.4   Rhodium-catalyzed hydrosilylation/cyclization reaction
 

Ref. Angew. Chem. Int. Ed. 2007, 46, 1275–1277.